Did Genetic Engineering Bring Back the Dire Wolf?
Colossal Biosciences received an upheaval of excitement as well as scientific criticism recently for ‘de-extincting’ the dire wolf, which they explain was accomplished by rewriting the genetic code of the modern gray wolf (Canis lupus) to match the genome of the dire wolf (Aenocyon dirus). This genome was extracted from two ancient samples lent by museums – a 13,000 year old tooth and a 72,000 year old ear bone – and analyzed to determine what genetic changes would be made. Scientists then extracted cells from a gray wolf and used CRISPR gene editing to make 20 edits in 14 key genes to express specific traits that match those of the dire wolf. The edited cells were used to create embryos, which were implanted into domestic dogs used as surrogate mothers to birth them into existence. However, no dire wolf DNA was actually spliced into the genome of the common gray wolf.
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